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Tissue Engineering: Stable Extracellular Matrix Protein Patterns Guide the Orientation of Osteoblast‐like Cells (Adv. Funct. Mater. 21/2011)
Author(s) -
Zhang JianTao,
Nie Juequan,
Mühlstädt Mike,
Gallagher Hilary,
Pullig Oliver,
Jandt Klaus D.
Publication year - 2011
Publication title -
advanced functional materials
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 6.069
H-Index - 322
eISSN - 1616-3028
pISSN - 1616-301X
DOI - 10.1002/adfm.201190097
Subject(s) - extracellular matrix , materials science , microcontact printing , osteoblast , adhesion , nanotechnology , cell adhesion , tissue engineering , microbiology and biotechnology , matrix (chemical analysis) , biophysics , biomedical engineering , biology , composite material , in vitro , biochemistry , medicine
On page 4079 , Jian‐Tao Zhang, Oliver Pullig, Klaus D. Jandt, and coworkers use a facile approach, microcontact printing, to fabricate stable extracellular matrix (ECM) protein microstructures on the surfaces of implant materials. These protein structures are highly stable due to an intermediate polymer layer between the ECM proteins and the materials. Interestingly, these structures can guide the adhesion, proliferation, and organization of osteoblast‐like cells. The cell morphology and alignment are controllable by the protein patterns.