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A Facile and General Method for the Encapsulation of Different Types of Imaging Contrast Agents Within Micrometer‐Sized Polymer Beads
Author(s) -
Bai MengYi,
Moran Christine H.,
Zhang Lei,
Liu Changjun,
Zhang Yu,
Wang Lihong V.,
Xia Younan
Publication year - 2012
Publication title -
advanced functional materials
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 6.069
H-Index - 322
eISSN - 1616-3028
pISSN - 1616-301X
DOI - 10.1002/adfm.201102582
Subject(s) - materials science , polystyrene , polymer , annealing (glass) , high contrast , glass transition , nanotechnology , chemical engineering , composite material , optics , physics , engineering
Abstract Polystyrene (PS) hollow beads with holes on the surfaces are employed as containers for quick loading and encapsulation of a variety of contrast enhancement agents: saline solutions for thermoacoustic tomography, iodinated organic compounds for micro‐computed tomography, and perfluorooctane for magnetic resonance. Because of the hole on the surface of the PS hollow bead, the contrast agent to be encapsulated could quickly enter the hollow interior via direct flow rather than slow diffusion through the wall. After loading, the hole on the surface is conveniently sealed by annealing the sample at a temperature (e.g., 95 °C) slightly above the glass‐transition temperature of PS. In vitro methods are also used to investigate the effectiveness of encapsulation by quantifying the contrast enhancement enabled by the contrast agents.