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Luminescent Metal‐Organic Frameworks for Selectively Sensing Nitric Oxide in an Aqueous Solution and in Living Cells
Author(s) -
Wu Pengyan,
Wang Jian,
He Cheng,
Zhang Xiaolin,
Wang Yanting,
Liu Tao,
Duan Chunying
Publication year - 2012
Publication title -
advanced functional materials
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 6.069
H-Index - 322
eISSN - 1616-3028
pISSN - 1616-301X
DOI - 10.1002/adfm.201102157
Subject(s) - triphenylamine , luminescence , europium , materials science , aqueous solution , fluorescence , lanthanide , photochemistry , metal organic framework , metal , inorganic chemistry , nuclear chemistry , ion , chemistry , organic chemistry , polymer chemistry , adsorption , optoelectronics , physics , quantum mechanics , metallurgy
Cu 2+ ‐based metal‐organic framework (Cu− TCA ) (H 3 TCA = tricarboxytriphenyl amine) having triphenylamine emitters was assembled and structurally characterized. Cu− TCA features a three‐dimensional porous structure consolidated by the well‐established Cu 2 (O 2 CR) 4 paddlewheel units with volume of the cavities approximately 4000 nm 3 . Having paramagnetic Cu 2+ ions to quench the luminescence of triphenylamine, Cu− TCA only exhibited very weak emission at 430 nm; upon the addition of NO up to 0.1 m M , the luminescence was recovered directly and provided about 700‐fold fluorescent enhancement. The luminescence detection exhibited high selectivity – other reactive species present in biological systems, including H 2 O 2 , NO 3 − , NO 2 − , ONOO − , ClO − and 1 O 2 , did not interfere with the NO detection. The brightness of the emission of Cu− TCA also led to its successful application in the biological imaging of NO in living cells. As a comparison, lanthanide metal‐organic framework Eu− TCA having triphenylamine emitters and characteristic europium emitters was also assembled. Eu− TCA exhibited ratiometric fluorescent responses towards NO with the europium luminescence maintained as the internal standard and the triphenylamine emission exhibited more than 1000‐fold enhancement.