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Design of an “Active Defense” System as Drug Carriers for Cancer Therapy
Author(s) -
Zhang Jing,
Xu XiaoDing,
Liu Yun,
Liu ChenWei,
Chen XiuHong,
Li Cao,
Zhuo RenXi,
Zhang XianZheng
Publication year - 2012
Publication title -
advanced functional materials
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 6.069
H-Index - 322
eISSN - 1616-3028
pISSN - 1616-301X
DOI - 10.1002/adfm.201102132
Subject(s) - drug , drug delivery , materials science , drug carrier , dextran , nanotechnology , targeted drug delivery , cancer cell , layer (electronics) , cancer therapy , cancer , biophysics , pharmacology , chemistry , biochemistry , medicine , biology
A novel intelligent “active defense” system that can specially respond to cancerous tissues for drug release was designed and prepared. The “active defense” system consists of a biodegradable dextran microgel core cross‐linked by a Schiff's base and a surrounding layer formed by Layer‐by‐Layer (LbL) assembly. The loading and release of macromolecular model drug, dex‐FITC, as well as antineoplastic drug, DOX, was investigated. The in vitro cell inhibition and drug release behavior of the drug delivery system were studied and the results showed that the entrapped drug could be explosively released from the microcapsules and thereafter taken up by cancer cells upon the trigger of the acidic environment around tumor tissues.