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Novel Triclosan‐Bound Hybrid‐Silica Nanoparticles and their Enhanced Antimicrobial Properties
Author(s) -
Makarovsky Igor,
Boguslavsky Yonit,
Alesker Maria,
Lellouche Jonathan,
Banin Ehud,
Lellouche JeanPaul
Publication year - 2011
Publication title -
advanced functional materials
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 6.069
H-Index - 322
eISSN - 1616-3028
pISSN - 1616-301X
DOI - 10.1002/adfm.201101557
Subject(s) - triclosan , antimicrobial , materials science , biocide , nanoparticle , covalent bond , nanotechnology , chemical engineering , combinatorial chemistry , microbiology and biotechnology , organic chemistry , chemistry , biology , medicine , engineering , pathology
The design and synthesis of novel hybrid‐silica nanoparticles (NPs) containing the FDA‐approved antimicrobial triclosan (Irgasan) covalently linked within the inorganic matrix for its controlled, slow release upon interaction, is reported. The NPs are in the range of 130 ± 30 nm in diameter, with a smooth and spherical morphology. Characterization of the hybrid‐silica NPs containing triclosan, namely T‐SNPs, and their appropriate linkers is accomplished by microscopic and spectroscopic techniques. Preliminary antimicrobial activity is studied through bacterial‐growth experiments. The T‐SNPs are found to be superior in killing bacteria, as compared with the free biocide.