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A Biosensor Based on Metallic Photonic Crystals for the Detection of Specific Bioreactions
Author(s) -
Zhang Xinping,
Ma Xuemei,
Dou Fei,
Zhao Pengxiang,
Liu Hongmei
Publication year - 2011
Publication title -
advanced functional materials
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 6.069
H-Index - 322
eISSN - 1616-3028
pISSN - 1616-301X
DOI - 10.1002/adfm.201101366
Subject(s) - biosensor , materials science , sensitivity (control systems) , surface plasmon resonance , photonics , photonic crystal , optoelectronics , nanotechnology , signal (programming language) , plasmon , nanoparticle , electronic engineering , computer science , engineering , programming language
An optical biosensor based on waveguided metallic photonic crystals (MPCs) is reported for the sensitive testing of biomolecular interactions, which provides practical approaches for the label‐free detection of specific bioreactions. The enhancement of the sensitivity or the amplification of the sensor signal by the coupling between the waveguide resonance mode and particle‐plasmon resonance (PPR) breaks through the “bottle‐neck” of the intrinsic response sensitivity defined by the spectral shift of the PPR. The success of this sensor is demonstrated by sensing the specific reaction between the HIV‐1 capsid protein (p24) antigen and the monoclonal anti‐p24 antibody, where the dynamics of the bioreactions can be recorded with a potentially high time resolution. This new sensor stands out due to its compact design and its new physics, compared with conventional devices, its simple operation, the simple fabrication of the MPC chip and the low cost of the whole system.