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Amino Acid Pairing for De Novo Design of Self‐Assembling Peptides and Their Drug Delivery Potential
Author(s) -
Fung ShanYu,
Yang Hong,
Sadatmousavi Parisa,
Sheng Yuebiao,
Mamo Tewodros,
Nazarian Reyhaneh,
Chen P.
Publication year - 2011
Publication title -
advanced functional materials
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 6.069
H-Index - 322
eISSN - 1616-3028
pISSN - 1616-301X
DOI - 10.1002/adfm.201002497
Subject(s) - hydrogen bond , amino acid , peptide , self assembly , nanomedicine , drug delivery , materials science , hydrophobic effect , ionic bonding , aqueous solution , pairing , combinatorial chemistry , nanotechnology , chemistry , molecule , organic chemistry , biochemistry , nanoparticle , ion , superconductivity , physics , quantum mechanics
Molecular self‐assembly has emerged as the “bottom‐up” engineering route to fabricate functional supramolecules for diverse applications. The design of molecular building units becomes critical in determining the structure, properties, and function of the resulting assemblies. Here, a de novo design principle of amino acid pairing (AAP) to generate new classes of self‐assembling peptides (SAPs) is presented. In this study, the AAP focuses on hydrogen bonding, and ionic and hydrophobic interactions among amino acid pairs. With solely hydrogen bond pairs, SAPs can be constructed with only two amino acids. With all three AAP strategies (hydrogen bonds, ionic and hydrophobic pairs), a short novel SAP is constructed. This peptide can self‐assemble into β‐sheet‐rich nanofibers with a relatively low “critical aggregation concentration (CAC)” of ∼10 μ M . It also shows the ability to stabilize and deliver the hydrophobic anticancer agent ellipticine in aqueous solution. The peptide‐drug complexes/co‐assemblies exhibit anticancer activity against human lung carcinoma cells A549 and breast cancer cells MCF‐7, and have good dilution stability. The presented AAP design provides a new strategy to fabricate functional supramolecules with potential applications in nanomedicine.