Premium
Doxorubicin Nanocarriers Based on Magnetic Colloids with a Bio‐polyelectrolyte Corona and High Non‐linear Optical Response: Synthesis, Characterization, and Properties
Author(s) -
Bakandritsos Aristides,
Mattheolabakis George,
Chatzikyriakos George,
Szabo Tamas,
Tzitzios Vasilis,
Kouzoudis Dimitris,
Couris Stelios,
Avgoustakis Konstantinos
Publication year - 2011
Publication title -
advanced functional materials
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 6.069
H-Index - 322
eISSN - 1616-3028
pISSN - 1616-301X
DOI - 10.1002/adfm.201002112
Subject(s) - nanocarriers , materials science , polyelectrolyte , polymer , colloid , magnetic hyperthermia , nanotechnology , chemical engineering , nanoparticle , magnetic nanoparticles , composite material , engineering
Magnetic drug nanocarriers are synthesized following an arrested mineralization of magnetic spinel iron oxides in the presence of the biopolymer of sodium carboxymethylcellulose. Based on the experimental results, the polyelectrolyte corona probably attains a brushlike configuration around the magnetic particles. The inner core of these colloids may be constituted of polymer‐associated nanocrystallites, forming nanogel colloids. The hybrid colloids are endowed with a high loading capacity for the anticancer agent doxorubicin and pronounced pH responsiveness. They also display a dramatic increase in non‐linear optical response as compared to previous studies of similar materials. Furthermore, as cell studies indicate, the blank nanocarriers are cytocompatible and the drug retains its activity after loading in the nanocarriers.