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Electrodeposition on Nanofibrous Polymer Scaffolds: Rapid Mineralization, Tunable Calcium Phosphate Composition and Topography
Author(s) -
He Chuanglong,
Xiao Guiyong,
Jin Xiaobing,
Sun Chenghui,
Ma Peter X.
Publication year - 2010
Publication title -
advanced functional materials
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 6.069
H-Index - 322
eISSN - 1616-3028
pISSN - 1616-301X
DOI - 10.1002/adfm.201000993
Subject(s) - materials science , electrospinning , polymer , coating , mineralization (soil science) , calcium , chemical engineering , biocompatible material , biomedical engineering , nanotechnology , composite material , chemistry , organic chemistry , medicine , nitrogen , engineering , metallurgy
A straightforward, fast and versatile technique to fabricate mineralized nanofibrous polymer scaffolds for bone regeneration is developed. Nanofibrous poly( L ‐lactic acid) scaffolds are fabricated using both electrospinning and phase separation techniques. An electrodeposition process is designed to deposit calcium phosphate on the nanofibrous scaffolds. Such scaffolds contain a high quality mineral coating on the fiber surface and have surface topography and chemical composition that are tunable by varying the processing parameters. These scaffolds can mimic the composition and structure of the natural bone extracellular matrix and provide a more biocompatible interface for bone regeneration.