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Chemiluminescence‐Generating Nanoreactor Formulation for Near‐Infrared Imaging of Hydrogen Peroxide and Glucose Level in vivo
Author(s) -
Lim ChangKeun,
Lee YongDeok,
Na Jinhee,
Oh Jung Min,
Her Song,
Kim Kwangmeyung,
Choi Kuiwon,
Kim Sehoon,
Kwon Ick Chan
Publication year - 2010
Publication title -
advanced functional materials
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 6.069
H-Index - 322
eISSN - 1616-3028
pISSN - 1616-301X
DOI - 10.1002/adfm.201000780
Subject(s) - chemiluminescence , hydrogen peroxide , nanoreactor , peroxyoxalate , cyanine , in vivo , materials science , nanoscopic scale , biophysics , reactive oxygen species , photochemistry , nanotechnology , nanoparticle , chemistry , fluorescence , biochemistry , biology , organic chemistry , optics , physics , microbiology and biotechnology
Water‐dispersed all‐in‐one nanoprobes composed of densely integrated peroxyoxalate fuel and a cyanine dye are formulated to optimize the nanoscopic chemiluminescence reaction. It is demonstrated that the chemiluminescent nanoformulation can generate bright near‐infrared signal in response to external hydrogen peroxide that is biologically implicated with cell signaling and diseases. Successful imaging of endogenously overproduces hydrogen peroxide and indirect determination of glucose level in vivo with the chemiluminescent nanoprobes offers an opportunity for early diagnosis of diseases.