Premium
A Three‐Dimensional and Sensitive Bioassay Based on Nanostructured Quartz Combined with Viral Nanoparticles
Author(s) -
Lee JongHwan,
Kim Jung Suk,
Park JinSeung,
Lee Wonbae,
Lee Kyung Eun,
Han SungSik,
Lee Kyu Back,
Lee Jeewon
Publication year - 2010
Publication title -
advanced functional materials
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 6.069
H-Index - 322
eISSN - 1616-3028
pISSN - 1616-301X
DOI - 10.1002/adfm.200902054
Subject(s) - materials science , quartz , nanotechnology , nanoparticle , capsid , etching (microfabrication) , nanostructure , hepatitis a virus , reactive ion etching , virus , virology , biology , composite material , layer (electronics)
An effective mask‐free method for fabricating high‐aspect‐ratio pillarlike nanostructures over a large area of a quartz surface via a simple O 2 and CF 4 two‐step reactive ion etching (RIE) procedure is developed. The nanostructured quartz surfaces are successfully combined with the engineered viral particles derived from hepatitis B virus capsid, yielding a novel 3D assay system with attomolar sensitivity, which has great potential for use in sensitive and early detection of various disease markers.