Premium
Smart Hydrogels Co‐switched by Hydrogen Bonds and π–π Stacking for Continuously Regulated Controlled‐Release System
Author(s) -
Li Fang,
Zhu Yingchun,
You Bo,
Zhao Donghui,
Ruan Qichao,
Zeng Yi,
Ding Chuanxian
Publication year - 2010
Publication title -
advanced functional materials
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 6.069
H-Index - 322
eISSN - 1616-3028
pISSN - 1616-301X
DOI - 10.1002/adfm.200901245
Subject(s) - self healing hydrogels , methacrylic acid , stacking , materials science , methacrylate , hydrogen bond , polymer , controlled release , polymer chemistry , swelling , ethylene glycol dimethacrylate , chemical engineering , molecule , diffusion , ethylene glycol , kinetics , monomer , organic chemistry , nanotechnology , chemistry , composite material , physics , engineering , thermodynamics , quantum mechanics
A series of hydrogels with continuously regulatable release behavior can be achieved by incorporating hydrogen bonding and π–π stacking co‐switches in polymers. A poly(nitrophenyl methacrylate‐ co ‐methacrylic acid) hydrogel (NPMAAHG) for control over drug release is fabricated by copolymerizing 4‐nitrophenyl methacrylate and methacrylic acid using ethylene glycol dimethacrylate as a crosslinker. The carboxylic acid groups and nitrylphenyl groups form hydrogen bonds and π–π stacking interactions, respectively, which act as switches to control the release of guest molecules from the polymers. As revealed by the simulated gastrointestinal tract drug release experiments, the as‐synthesized NPMAAHG hydrogels can be regulated to release only 4.7% of drugs after 3 h in a simulated stomach and nearly 92.6% within 43 h in the whole digestive tract. The relation between the release kinetics and structures and the mechanism of the smart release control are analyzed in terms of diffusion exponent, swelling interface number, drug diffusion coefficient, and velocity of the swelling interface in detail. The results reveal that the release of guest molecules from the hydrogels can be continuously regulated for systemic administration by controlling the ratio of the hydrophilic hydrogen bonds and the hydrophobic π–π stacking switches.