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Nanoshells with Targeted Simultaneous Enhancement of Magnetic and Optical Imaging and Photothermal Therapeutic Response
Author(s) -
Bardhan Rizia,
Chen Wenxue,
PerezTorres Carlos,
Bartels Marc,
Huschka Ryan M.,
Zhao Liang L.,
Morosan Emilia,
Pautler Robia G.,
Joshi Amit,
Halas Naomi J.
Publication year - 2009
Publication title -
advanced functional materials
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 6.069
H-Index - 322
eISSN - 1616-3028
pISSN - 1616-301X
DOI - 10.1002/adfm.200901235
Subject(s) - nanoshell , photothermal therapy , materials science , nanotechnology , nanoscopic scale , fluorescence , bioconjugation , magnetic resonance imaging , fluorophore , photothermal effect , optical imaging , indocyanine green , biomedical engineering , nanoparticle , optics , physics , medicine , radiology
Integrating multiple functionalities into individual nanoscale complexes is of tremendous importance in biomedicine, expanding the capabilities of nanoscale structures to perform multiple parallel tasks. Here, the ability to enhance two different imaging technologies simultaneously—fluorescence optical imaging and magnetic resonance imaging—with antibody targeting and photothermal therapeutic actuation is combined all within the same nanoshell‐based complex. The nanocomplexes are constructed by coating a gold nanoshell with a silica epilayer doped with Fe 3 O 4 and the fluorophore ICG, which results in a high T 2 relaxivity (390 m M −1 s −1 ) and 45× fluorescence enhancement of ICG. Bioconjugate nanocomplexes target HER2+ cells and induce photothermal cell death upon near‐IR illumination.