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Cover Picture: Surface Engineered Carboxymethylchitosan/Poly(amidoamine) Dendrimer Nanoparticles for Intracellular Targeting (Adv. Funct. Mater. 12/2008)
Author(s) -
Oliveira Joaquim M.,
Kotobuki Noriko,
Marques Alexandra P.,
Pirraco Rogério P.,
Benesch Johan,
Hirose Motohiro,
Costa Silgia A.,
Mano João F.,
Ohgushi Hajime,
Reis Rui L.
Publication year - 2008
Publication title -
advanced functional materials
Language(s) - English
Resource type - Reports
SCImago Journal Rank - 6.069
H-Index - 322
eISSN - 1616-3028
pISSN - 1616-301X
DOI - 10.1002/adfm.200890045
Subject(s) - dendrimer , materials science , poly(amidoamine) , drug delivery , amidoamine , nanoparticle , chitosan , biocompatible material , intracellular , nanotechnology , tissue engineering , surface modification , biophysics , chemical engineering , polymer chemistry , chemistry , biomedical engineering , organic chemistry , biochemistry , biology , engineering , medicine
Highly branched, biodegradable, biocompatible macromolecular systems were developed by surface engineering poly(amidoamine) dendrimer nanoparticles with a water‐soluble chitosan derivative, as reported by Joaquim M. Oliveira and co‐workers on p. 1840 . These structures were organized into sphere‐like nanoparticles that have the potential to be used as intracellular drug‐delivery carriers for a wide range of applications that require efficient intracellular delivery of biological agents tomodulate the behavior of stem cells, for example, their proliferation and differentiation. These applications might include the use of differentiation factors to act within cells (see cover) or genetic material.