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Cover Picture: Self‐assembled Cationic Peptide Nanoparticles Capable of Inducing Efficient Gene Expression In Vitro (Adv. Funct. Mater. 6/2008)
Author(s) -
Wiradharma Nikken,
Khan Majad,
Tong Yen Wah,
Wang Shu,
Yang YiYan
Publication year - 2008
Publication title -
advanced functional materials
Language(s) - English
Resource type - Reports
SCImago Journal Rank - 6.069
H-Index - 322
eISSN - 1616-3028
pISSN - 1616-301X
DOI - 10.1002/adfm.200890023
Subject(s) - oligopeptide , nanoparticle , in vitro , cationic polymerization , materials science , peptide , amphiphile , gene delivery , dna , self assembly , gene expression , biophysics , cytotoxicity , nanotechnology , gene , biochemistry , transfection , biology , polymer chemistry , polymer , copolymer , composite material
On p. 943 , Yi‐Yan Yang and co‐workers report on cationic and amphiphilic oligopeptides as nonviral vectors for gene delivery. The oligopeptides were able to self‐assemble into core/shell nanoparticles at concentrations above the CMC value. The formation of the nanoparticles yielded a greater local concentration of positive charges, providing a stronger DNA binding ability, thus efficiently preventing DNA from enzymatic degradation. The peptide nanoparticles had little cytotoxicity against cell lines but did induce high gene expression levels in vitro.