Premium
Supercritical‐Fluid‐Assisted One‐Pot Synthesis of Biocompatible Core( γ ‐Fe 2 O 3 )/Shell(SiO 2 ) Nanoparticles as High Relaxivity T 2 ‐Contrast Agents for Magnetic Resonance Imaging
Author(s) -
Taboada Elena,
Solanas Raul,
Rodríguez Elisenda,
Weissleder Ralph,
Roig Anna
Publication year - 2009
Publication title -
advanced functional materials
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 6.069
H-Index - 322
eISSN - 1616-3028
pISSN - 1616-301X
DOI - 10.1002/adfm.200801681
Subject(s) - materials science , dispersity , superparamagnetism , supercritical fluid , maghemite , microporous material , nanoparticle , chemical engineering , nanotechnology , magnetization , fabrication , yield (engineering) , composite material , organic chemistry , polymer chemistry , magnetic field , engineering , chemistry , physics , quantum mechanics , medicine , alternative medicine , pathology
Abstract Monodisperse iron oxide/microporous silica core/shell composite nanoparticles, core( γ ‐Fe 2 O 3 )/shell(SiO 2 ), with a diameter of approximately 100 nm and a high magnetization are synthesized by combining sol–gel chemistry and supercritical fluid technology. This one‐step processing method, which is easily scalable, allows quick fabrication of materials with controlled properties and in high yield. The particles have a specific magnetic moment (per kg of iron) comparable to that of the bulk maghemite and show superparamagnetic behavior at room temperature. The nanocomposites are proven to be useful as T 2 MRI imaging agent. They also have potential to be used in NMR proximity sensing, theranostic drug delivery, and bioseparation.