Premium
Bifunctional Gd 2 O 3 /C Nanoshells for MR Imaging and NIR Therapeutic Applications
Author(s) -
Huang ChihChia,
Su ChiaHao,
Li WeiMing,
Liu TzuYu,
Chen JyhHorng,
Yeh ChenSheng
Publication year - 2009
Publication title -
advanced functional materials
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 6.069
H-Index - 322
eISSN - 1616-3028
pISSN - 1616-301X
DOI - 10.1002/adfm.200801454
Subject(s) - nanoshell , materials science , photothermal therapy , biodistribution , nanotechnology , nanoparticle , ethylene glycol , in vivo , chemistry , organic chemistry , microbiology and biotechnology , biology
This paper reports dual function Gd 2 O 3 /C nanoshells for application in MR contrast images and NIR‐triggered killing cancer cells. The nanoshells are prepared using biological gelatin particles as core templates through a two‐step thermal treatment. The surfaces of the nanoshells can be readily modified by poly(styrene‐alt‐maleic acid) (PSMA) polymer to improve their water‐dispersible properties and increase their biocompatibility. The Gd 2 O 3 /C nanoshells show brightened images of kidney cortex and liver in mice, whereas the Gd 2 O 3 /C@PSMA nanoshells show a darkened liver signal. The biodistribution is measured as a function of time and shows that the nanoshells circulate in the vessels and are cleared out gradually from organs. The graphite carbon coated on the Gd 2 O 3 nanoshells displays absorbance in the near‐IR (NIR) region. A large extinction coefficient is obtained, indicating the potential of the nanoshells as photothermal agents. The Gd 2 O 3 /C@PSMA nanoshells conjugated with anti‐epithermal growth factor receptor antibodies are used for targeting and destroying A549 lung cancer cells by means of NIR‐triggered killing capability. Both laser power density and material dose dependence are investigated to evaluate photothermolysis in cancer cells.