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Nanoaggregate‐Embedded Beads as Novel Raman Labels for Biodetection
Author(s) -
Huang PingJi,
Chau LaiKwan,
Yang TzyySchiuan,
Tay LiLin,
Lin TaiTsung
Publication year - 2009
Publication title -
advanced functional materials
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 6.069
H-Index - 322
eISSN - 1616-3028
pISSN - 1616-301X
DOI - 10.1002/adfm.200800961
Subject(s) - raman spectroscopy , materials science , raman scattering , nanotechnology , nanoparticle , colloidal gold , optics , physics
Novel Raman tags called nanoaggregate‐embedded beads (NAEBs) have been developed. NAEBs are silica‐coated, dye‐induced aggregates of a small number of metal nanoparticles. In this work, the Raman reporters used to induce aggregation of gold nanoparticles include strongly binding dyes such as XRITC, TRITC, and DTDC and weakly binding dyes such as R6G. Surface‐enhanced Raman scattering (SERS) signal from a single NAEB can be detected. This study also demonstrates that these SERS‐active beads can be used as Raman tags for bio‐detection.