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Novel Engineered Ion Channel Provides Controllable Ion Permeability for Polyelectrolyte Microcapsules Coated with a Lipid Membrane
Author(s) -
Battle Andrew R.,
Valenzuela Stella M.,
Mechler Adam,
Nichols Ryan J.,
Praporski Slavica,
di Maio Isabelle L.,
Islam Hedayetul,
GirardEgrot Agnès P.,
Cornell Bruce A.,
Prashar Jog,
Caruso Frank,
Martin Lisandra L.,
Martin Donald K.
Publication year - 2009
Publication title -
advanced functional materials
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 6.069
H-Index - 322
eISSN - 1616-3028
pISSN - 1616-301X
DOI - 10.1002/adfm.200800483
Subject(s) - polyelectrolyte , materials science , membrane , lipid bilayer , allylamine , permeation , nanotechnology , coating , gramicidin , ion transporter , chemical engineering , drug delivery , polymer , chemistry , composite material , biochemistry , engineering
Abstract The development of nanostructured microcapsules based on a biomimetic lipid bilayer membrane (BLM) coating of poly(sodium styrenesulfonate) (PSS)/poly(allylamine hydrochloride) (PAH) polyelectrolyte hollow microcapsules is reported. A novel engineered ion channel, gramicidin (bis‐gA), incorporated into the lipid membrane coating provides a functional capability to control transport across the microcapsule wall. The microcapsules provide transport and permeation for drug‐analog neutral species, as well as positively and negatively charged ionic species. This controlled transport can be tuned for selective release biomimetically by controlling the gating of incorporated bis‐gA ion channels. This system provides a platform for the creation of “smart” biomimetic delivery vessels for the effective and selective therapeutic delivery and targeting of drugs.