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Biocompatible, Luminescent Silver@Phenol Formaldehyde Resin Core/Shell Nanospheres: Large‐Scale Synthesis and Application for In Vivo Bioimaging
Author(s) -
Guo ShiRui,
Gong JunYan,
Jiang Peng,
Wu Mian,
Lu Yang,
Yu ShuHong
Publication year - 2008
Publication title -
advanced functional materials
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 6.069
H-Index - 322
eISSN - 1616-3028
pISSN - 1616-301X
DOI - 10.1002/adfm.200701440
Subject(s) - biocompatible material , materials science , dispersity , nanotechnology , nanoparticle , luminescence , polymerization , chemical engineering , polymer , polymer chemistry , composite material , biomedical engineering , medicine , optoelectronics , engineering
Biocompatible and green luminescent monodisperse silver/phenol formaldehyde resin core/shell spheres with controllable sizes, in the range of 180 to 1000 nm, and interesting architectures (centric, eccentric, and coenocytic core/shell spheres) have been synthesized by a facile one‐step hydrothermal approach. These spheres can be used as bioimaging labels for human lung cancer H1299 cells. The results demonstrate that the nanoparticles can be internalized into cells and exhibit no cytotoxic effects, showing that such novel biocompatible core/shell structures can potentially be used as in vivo bioimaging labels. This facile one‐pot polymerization and encapsulation technique may provide a useful tool to synthesize other core/shell particles that have potential application in biotechnology.