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Polymer Microcapsules with Carbohydrate‐Sensitive Properties
Author(s) -
Levy Tatjana,
Déjugnat Christophe,
Sukhorukov Gleb B.
Publication year - 2008
Publication title -
advanced functional materials
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 6.069
H-Index - 322
eISSN - 1616-3028
pISSN - 1616-301X
DOI - 10.1002/adfm.200701291
Subject(s) - mannan , phenylboronic acid , boronic acid , polymer , bovine serum albumin , materials science , polysaccharide , carbohydrate , fructose , acrylic acid , polymer chemistry , dissolution , covalent bond , chemical engineering , organic chemistry , chemistry , chromatography , copolymer , catalysis , engineering
Abstract Carbohydrate‐sensitive polymer multilayers are assembled onto flat substrates and colloidal CaCO 3 particles via reversible covalent ester formation between the polysaccharide mannan and phenylboronic acid moieties grafted onto poly(acrylic acid) (PAA). The resulting multilayer films are sensitive to several carbohydrates, and show the highest sensitivity to fructose. The response to carbohydrates arises from the competitive binding of small molecular weight sugars and mannan to boronic acid groups within the films, and is observed as a rapid dissolution of the multilayers upon contact with a sugar‐containing solution above a critical concentration. In addition, carbohydrate‐sensitive multilayer capsules are prepared, and their sugar‐dependent stability is investigated by following the release of encapsulated tetramethylrhodamine isothiocyanate‐bovine serum albumin (TRITC‐BSA).