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Multifunctional Magnetic Gold Nanocomposites: Human Epithelial Cancer Detection via Magnetic Resonance Imaging and Localized Synchronous Therapy
Author(s) -
Lee J.,
Yang J.,
Ko H.,
Oh S.,
Kang J.,
Son J.,
Lee K.,
Lee S.W.,
Yoon H.G.,
Suh J.S.,
Huh Y.M.,
Haam S.
Publication year - 2008
Publication title -
advanced functional materials
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 6.069
H-Index - 322
eISSN - 1616-3028
pISSN - 1616-301X
DOI - 10.1002/adfm.200700482
Subject(s) - materials science , magnetic resonance imaging , conjugated system , surface plasmon resonance , cancer cell , nuclear magnetic resonance , cancer , nanotechnology , cancer research , nanoparticle , polymer , medicine , radiology , physics , composite material
Novel multifunctional magnetic gold nanocomposites (MGNCs) were synthesized for synchronous cancer therapy and diagnosis via magnetic resonance imaging (MRI). The MGNCs consist of magnetic kernels (aggregates of ultra‐sensitive MnFe 2 O 4 magnetic nanocrystals wrapped in polymer) as effective MR contrast agents and silica–gold nanocomposites as hyperthermal therapeutic agents. A therapeutic antibody, Erbitux (ERB), was conjugated for specific tumor cell targeting both to localize the near‐IR laser beam and to image their events through MRI. ERB‐conjugated MGNCs selectively recognize the target cancer cell lines. Fluorescence images and MRI analysis show that the MGNCs are effectively taken up by the cells. ERB‐conjugated MGNCs have an excellent synchronous therapeutic efficacy as a result of the therapeutic antibody and near‐IR laser‐induced surface plasmon resonance. Consequently, MGNCs clearly demonstrate selective imaging and treatment of human epithelial cancer simultaneously.