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Antibody‐Functionalized Hybrid Superparamagnetic Nanoparticles
Author(s) -
Arruebo M.,
FernándezPacheco R.,
Velasco B.,
Marquina C.,
Arbiol J.,
Irusta S.,
Ibarra M. R.,
Santamaría J.
Publication year - 2007
Publication title -
advanced functional materials
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 6.069
H-Index - 322
eISSN - 1616-3028
pISSN - 1616-301X
DOI - 10.1002/adfm.200600560
Subject(s) - superparamagnetism , materials science , nanoparticle , conjugated system , covalent bond , iron oxide nanoparticles , nanotechnology , magnetic nanoparticles , chemical engineering , magnetization , organic chemistry , polymer , chemistry , physics , quantum mechanics , magnetic field , engineering , composite material
Superparamagnetic hybrid nanoparticles (ca. 80 nm) are obtained. They consist of an inner iron oxide core coated by a silica shell, which is in turn functionalized with amine or carboxyl groups and covalently coupled to a monoclonal antibody (anti‐hCG; hCG = human chorionic gonadotropin). The prepared nanoparticles show a specific magnetic moment (per gram of iron) that is comparable to that measured for commercial superparamagnetic iron oxide preparations. The bioactivity of the antibody‐conjugated magnetic nanoparticles is verified by a standard bioassay. These results indicate the potential of the hybrid nanoparticles prepared for use as enhanced contrast agents in magnetic resonance imaging applications.