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Self‐Assembly of a Micelle Structure from Graft and Diblock Copolymers: An Example of Overcoming the Limitations of Polyions in Drug Delivery
Author(s) -
Lo C.L.,
Lin K.M.,
Huang C.K.,
Hsiue G.H.
Publication year - 2006
Publication title -
advanced functional materials
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 6.069
H-Index - 322
eISSN - 1616-3028
pISSN - 1616-301X
DOI - 10.1002/adfm.200500627
Subject(s) - copolymer , micelle , materials science , ethylene glycol , drug delivery , polymer chemistry , lactide , chemical engineering , organic chemistry , nanotechnology , polymer , chemistry , aqueous solution , composite material , engineering
A novel mixed micelle with a multifunctional core and shell is successfully prepared from a graft copolymer, poly( N ‐isopropyl acrylamide‐ co ‐methacrylic acid)‐ g ‐poly( d,l ‐lactide) (P(NIPAAm‐ co ‐MAAc)‐ g ‐PLA) and two diblock copolymers, poly(ethylene glycol)‐ b ‐poly( d,l ‐lactide) and poly (2‐ethyl‐2‐oxazoline)‐ b ‐poly( d,l ‐lactide). This nanostructure completely screens the highly negative charges of the graft copolymer and exhibits multifunctionality because it has a specialized core/shell structure. An example of this micelle structure used in intracellular drug delivery demonstrates a strong relationship between drug release and the functionality of the mixed micelle. Additionally, the efficiency of the screening feature is also displayed in the cytotoxicities; mixed micelles exhibit higher drug activity and lower material cytotoxicity than micelles from P(NIPAAm‐ co ‐MAAc)‐ g ‐PLA ([NIPAAm]/[MAAc]/[PLA] = 84:5.9:2.5 mol/mol) copolymer. This study not only presents a new micelle structure generated using a graft–diblock copolymer system, but also elucidates concepts upon which the preparation of a multifunctional micelle from a graft copolymer with a single (or many) diblock copolymer(s) can be based for applications in drug delivery.