Pyridylamino‐β‐cyclodextrin as a Molecular Chaperone for Lipopolysaccharide Embedded in a Multilayered Polyelectrolyte Architecture | Zendy

Jessel N. B. | Zendy; Schwinté P. | Zendy; Donohue R. | Zendy; Lavalle P. | Zendy; Boulmedais F. | Zendy; Darcy R. | Zendy; Szalontai B. | Zendy; Voegel J.C. | Zendy; Ogier J. | Zendy

Premium

Pyridylamino‐β‐cyclodextrin as a Molecular Chaperone for Lipopolysaccharide Embedded in a Multilayered Polyelectrolyte Architecture

Author(s) -

Jessel N. B.,

Schwinté P.,

Donohue R.,

Lavalle P.,

Boulmedais F.,

Darcy R.,

Szalontai B.,

Voegel J.C.,

Ogier J.

Publication year - 2004

Publication title -

advanced functional materials

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 6.069

H-Index - 322

eISSN - 1616-3028

pISSN - 1616-301X

DOI - 10.1002/adfm.200305089

Subject(s) - cyclodextrin , polyelectrolyte , lipopolysaccharide , lysine , materials science , chaperone (clinical) , glutamic acid , molecule , biophysics , chemical engineering , amino acid , organic chemistry , chemistry , biochemistry , polymer , biology , medicine , pathology , composite material , engineering , endocrinology

Layer‐by‐layer self‐assembled polyelectrolyte films containing a charged cyclodextrin and lipopolysaccharide (LPS) are developed for the first time as a potential model for local endotoxin antagonist delivery. We have examined the biological activity of a lipopolysaccharide from E. coli incorporated into multilayered architectures made of poly‐( L ‐lysine) and poly‐( L ‐glutamic acid). Used in such build‐ups, a polycationic cyclodextrin, heptakis(6‐deoxy‐6‐pyridylamino)‐β‐cyclodextrin showed molecular chaperone properties by enabling restoration of the LPS biological activity whenever lost upon interaction with poly‐( L ‐lysine).

This content is not available in your region!

Continue researching here.

Having issues? You can contact us here

Accelerating Research