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Pyridylamino‐β‐cyclodextrin as a Molecular Chaperone for Lipopolysaccharide Embedded in a Multilayered Polyelectrolyte Architecture
Author(s) -
Jessel N. B.,
Schwinté P.,
Donohue R.,
Lavalle P.,
Boulmedais F.,
Darcy R.,
Szalontai B.,
Voegel J.C.,
Ogier J.
Publication year - 2004
Publication title -
advanced functional materials
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 6.069
H-Index - 322
eISSN - 1616-3028
pISSN - 1616-301X
DOI - 10.1002/adfm.200305089
Subject(s) - cyclodextrin , polyelectrolyte , lipopolysaccharide , lysine , materials science , chaperone (clinical) , glutamic acid , molecule , biophysics , chemical engineering , amino acid , organic chemistry , chemistry , biochemistry , polymer , biology , medicine , pathology , composite material , engineering , endocrinology
Abstract Layer‐by‐layer self‐assembled polyelectrolyte films containing a charged cyclodextrin and lipopolysaccharide (LPS) are developed for the first time as a potential model for local endotoxin antagonist delivery. We have examined the biological activity of a lipopolysaccharide from E. coli incorporated into multilayered architectures made of poly‐( L ‐lysine) and poly‐( L ‐glutamic acid). Used in such build‐ups, a polycationic cyclodextrin, heptakis(6‐deoxy‐6‐pyridylamino)‐β‐cyclodextrin showed molecular chaperone properties by enabling restoration of the LPS biological activity whenever lost upon interaction with poly‐( L ‐lysine).