Hollow Microneedle Arrays Produced by Low‐Cost, High‐Fidelity Replication of Hypodermic Needle Tips for High‐Dose Transdermal Drug Delivery | Zendy

Zhou Cuiping | Zendy; Tang Hao | Zendy; Zhang Li | Zendy; An Hong | Zendy; Wu Yunjin | Zendy; Tang Ding | Zendy; Zhou Jianhua | Zendy

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Hollow Microneedle Arrays Produced by Low‐Cost, High‐Fidelity Replication of Hypodermic Needle Tips for High‐Dose Transdermal Drug Delivery

Author(s) -

Zhou Cuiping,

Tang Hao,

Zhang Li,

An Hong,

Wu Yunjin,

Tang Ding,

Zhou Jianhua

Publication year - 2021

Publication title -

advanced engineering materials

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 0.938

H-Index - 114

eISSN - 1527-2648

pISSN - 1438-1656

DOI - 10.1002/adem.202170020

Subject(s) - transdermal , materials science , nanotechnology , microfluidic chip , replication (statistics) , microfluidics , chip , biomedical engineering , hypodermic needle , computer science , pharmacology , engineering , mechanical engineering , medicine , telecommunications , syringe , virology

Hollow microneedle arrays (HMN), which exhibit advantages like safety in use, painlessness, high drug loading, precise administration and convenience of connecting to external devices, have been massively produced via a simple, low‐cost and high‐fidelity replication strategy. The as‐obtained HMN could be integrated onto a microfluidic chip with different microchannels, and the microfluidic chip could be further applied to fabricate a bundle device by attaching the chip to a looped zip tie. By using this zip tie, vaccines or drugs could be loaded in a convenient way, as described in the article, number 2001355 , by Jianhua Zhou and co‐workers.

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