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Hollow Microneedle Arrays Produced by Low‐Cost, High‐Fidelity Replication of Hypodermic Needle Tips for High‐Dose Transdermal Drug Delivery
Author(s) -
Zhou Cuiping,
Tang Hao,
Zhang Li,
An Hong,
Wu Yunjin,
Tang Ding,
Zhou Jianhua
Publication year - 2021
Publication title -
advanced engineering materials
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.938
H-Index - 114
eISSN - 1527-2648
pISSN - 1438-1656
DOI - 10.1002/adem.202170020
Subject(s) - transdermal , materials science , nanotechnology , microfluidic chip , replication (statistics) , microfluidics , chip , biomedical engineering , hypodermic needle , computer science , pharmacology , engineering , mechanical engineering , medicine , telecommunications , syringe , virology
Hollow microneedle arrays (HMN), which exhibit advantages like safety in use, painlessness, high drug loading, precise administration and convenience of connecting to external devices, have been massively produced via a simple, low‐cost and high‐fidelity replication strategy. The as‐obtained HMN could be integrated onto a microfluidic chip with different microchannels, and the microfluidic chip could be further applied to fabricate a bundle device by attaching the chip to a looped zip tie. By using this zip tie, vaccines or drugs could be loaded in a convenient way, as described in the article, number 2001355 , by Jianhua Zhou and co‐workers.