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Developing a New Beta‐Type of Ti–Si/Sn Alloys for Targeted Orthopedic Therapeutics: Assessments of Biological Characteristics
Author(s) -
Xin Xirui,
Yu Hongqiang,
Lv Huixin,
Ren Jingyi,
Yu Wanqi,
Ding Xinxin,
Zhou Yanmin,
Zhao Jinghui
Publication year - 2021
Publication title -
advanced engineering materials
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.938
H-Index - 114
eISSN - 1527-2648
pISSN - 1438-1656
DOI - 10.1002/adem.202000430
Subject(s) - materials science , biocompatibility , spark plasma sintering , alloy , titanium alloy , metallurgy , titanium , cytotoxicity , corrosion , sintering , biomedical engineering , in vitro , chemistry , medicine , biochemistry
Titanium (Ti) alloys are widely used in tissue engineering, but their applications are limited by low strength, bactericidal properties, and metal ion release. Beta Ti alloys are promising materials for load‐bearing orthopedic implants due to their excellent corrosion resistance and high biocompatibility. Herein, developed new beta‐Ti alloys including Ti–Nb–Zr–Sn (Ti–Sn) and Ti–Nb–Zr–Ta–Si (Ti–Si) to improve structural and biochemical features of the existing Ti alloys as orthopedic implants. The new Ti–Sn and Ti–Si alloys were fabricated using mechanical ball milling and spark plasma sintering techniques respectively and compared with commercially pure Ti alloys on hydrophilicity, surface characteristics and cytotoxicity, proliferative and osteogenic differentiation effects as well as biocompatibility in human bone osteosarcoma cell line (MG63). The new beta Ti alloys showed no significant differences in proliferation and cytotoxicity on the MG63 cells. Both Ti–Sn and Ti–Si alloys, compared to the commercial pure Ti, improved the biological profile and upregulated the expressions of runt‐related transcription factor 2, osterix, and collagen mRNA levels in the MG63 cells. The Ti–Si alloy showed greater cell proliferation and osteoblastic protein expression and a better biological profile compared to the Ti and Ti–Sn alloys. The novel beta Ti alloys exhibited promising potentials in orthopedic applications.