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Shape Matters: Crystal Morphology and Surface Topography Alter Bioactivity of Bioceramics in Simulated Body Fluid
Author(s) -
Myszka Barbara,
Schodder Philipp I.,
Leupold Simon,
Barr Maïssa K. S.,
Hurle Katrin,
Schüßler Martina,
Demmert Benedikt,
Biggemann Jonas,
Fey Tobias,
Boccaccini Aldo R.,
Wolf Stephan E.
Publication year - 2020
Publication title -
advanced engineering materials
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.938
H-Index - 114
eISSN - 1527-2648
pISSN - 1438-1656
DOI - 10.1002/adem.202000044
Subject(s) - bioceramic , simulated body fluid , biomaterial , calcite , materials science , morphology (biology) , microstructure , crystal (programming language) , chemical engineering , nanotechnology , mineralogy , composite material , chemistry , scanning electron microscope , geology , paleontology , computer science , engineering , programming language
For bioactive biomaterials such as bioceramics and bioglass, it is generally accepted that, apart from acting as heterogeneous nucleators, it is their solubility and the resulting release of relevant ions such as calcium or basic anions which mainly governs the biomaterial's bioactivity. This contribution reveals that this bioactivity, as assessed by simulated body fluid (SBF), can also be considerably modified by the bioceramic's morphology, i.e., bioactivity is also governed by microstructure and surface morphology. When crystals are forced to adopt out‐of‐equilibrium crystal habit, this simple change in morphology converts an essentially bioinert material, here calcite, into a bioceramic which shows bioactivity in SBF. On larger length scales, already simple morphological changes, such as scratches, can have inverse effects. Limited mass transport into grooves and pits on a bioceramic surface can lead to local ion depletion which, in turn, causes reduced bioactivity of bioceramics which, otherwise, show distinct bioactivity in SBF. This contribution emblematically illustrates the unforeseen importance of even minor morphology changes on different length scales when assessing and designing a biomaterial's bioactivity through SBF assays.