Premium
Advanced Manufacturing of Patient‐Specific Occluders for the Left Atrial Appendage with Minimally Invasive Delivery
Author(s) -
Alaie Seyedhamidreza,
Robinson Sanlin S.,
Amiri Moghadam Amir Ali,
Augé Jordyn,
Caprio Alexandre,
Kolli Kranthi,
Al'Aref Subhi J.,
Min James K.,
Mosadegh Bobak,
Dunham Simon
Publication year - 2020
Publication title -
advanced engineering materials
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.938
H-Index - 114
eISSN - 1527-2648
pISSN - 1438-1656
DOI - 10.1002/adem.201901074
Subject(s) - appendage , biomedical engineering , 3d printed , intracardiac injection , inflatable , rapid prototyping , implant , 3d printing , materials science , catheter , atrial fibrillation , medicine , radiology , surgery , cardiology , mechanical engineering , engineering , anatomy , composite material
A novel method for the rapid prototyping of personalized inflatable left atrial appendage occluders, suitable for minimally invasive delivery, is demonstrated. The method allows for the design, fabrication, and quantitative testing of implants based on an individual's computed tomography (CT) scan. The performance of a left atrial appendage occluder by characterizing its ability to anchor, prevent leaks, and not obstruct the left atrium is reported on. The design of the occluder by varying features such as size, inflation fluids, and surface patterns is optimized. The implant, and its delivery via a minimally invasive catheter, is demonstrated in a 3D‐printed left atrial model. Herein, the way for leveraging advanced manufacturing and imaging technologies for the development of personalized intracardiac implants for transcatheter delivery is described.