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Combinatorial Development and In Vitro Characterization of the Quaternary Zr–Ti–X–Y (X–Y = Cu–Ag/Co–Ni) Metallic Glass for Prospective Bioimplants
Author(s) -
Jabed Akib,
Rahman Zia Ur,
Khan Muhammad Mudasser,
Haider Waseem,
Shabib Ishraq
Publication year - 2019
Publication title -
advanced engineering materials
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.938
H-Index - 114
eISSN - 1527-2648
pISSN - 1438-1656
DOI - 10.1002/adem.201900726
Subject(s) - materials science , corrosion , electrochemistry , biocompatibility , transmission electron microscopy , titanium , sputter deposition , metal , metallurgy , chemical engineering , sputtering , nanotechnology , thin film , electrode , chemistry , engineering
The prospect of Zr‐based metallic glasses (MGs) in achieving a combination of properties, such as excellent electrochemical properties and extended biocompatibility, has been studied in this work. The combinatorial method (magnetron co‐sputtering) has been adopted to fabricate two novel quaternary MG systems (Zr 50 Ti 32 Cu 13 Ag 5 and Zr 40 Ti 37 Co 12 Ni 11 ) with optimized compositions. The structural analysis has been performed by the grazing incidence x‐ray diffraction and high‐resolution transmission electron microscopy to affirm the disordered structure of the MG systems. The electrochemical analysis demonstrates lower corrosion‐ (0.10 and 0.04 μA cm −2 ), and passive (2.93 and 1.88 μA cm −2 ) current densities of the MGs. In addition, the MGs are found to have higher charge transfer resistance (4.70 and 7.86 MΩ cm 2 ) compared to the 316L stainless steel (SS) (0.15 MΩ cm 2 ) and cp‐Ti (0.53 MΩ cm 2 ). The electrochemical features are indicative towards higher corrosion‐resistance capabilities of Zr 50 Ti 32 Cu 13 Ag 5 and Zr 40 Ti 37 Co 12 Ni 11 MGs to prevent adverse biological reactions. Additionally, the cell proliferation analysis manifests higher cell proliferation on the Zr 50 Ti 32 Cu 13 Ag 5 and Zr 40 Ti 37 Co 12 Ni 11 MGs for the MC3T3‐E1 preosteoblast cells. Besides, the MTS assay analysis strengthens the prediction of cytocompatibility of the MGs. The integration of such unique properties makes these MG systems ideal candidates for biomedical implants.