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Novel Antibacterial and Bioactive Silicate Glass Nanoparticles for Biomedical Applications
Author(s) -
Vale Ana Catarina,
Carvalho Ana Luísa,
Barbosa Ana Margarida,
Torrado Egídio,
Mano João F.,
Alves Natália M.
Publication year - 2018
Publication title -
advanced engineering materials
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.938
H-Index - 114
eISSN - 1527-2648
pISSN - 1438-1656
DOI - 10.1002/adem.201700855
Subject(s) - fourier transform infrared spectroscopy , materials science , bioactive glass , scanning electron microscope , silicate , nanoparticle , particle size , simulated body fluid , siloxane , amorphous solid , zeta potential , chemical engineering , antibacterial activity , sol gel , nuclear chemistry , mineralogy , nanotechnology , crystallography , chemistry , composite material , polymer , bacteria , biology , engineering , genetics
In this work, the authors propose a new quick sol–gel procedure for bioglass nanoparticles production containing 10% mol of silver (AgBGs). These new AgBGs are characterized by Zeta potential analysis, scanning electron microscopy with X‐ray microanalysis (SEM/EDS), X‐ray powder diffraction (XRD), Fourier transform infrared spectroscopy (FTIR), and microbiological tests to confirm their bioactive and antibacterial properties. SEM shows that the average particle size is less than 200 nm and EDS confirms the successful incorporation of Ag 2 O in the bioglass matrix. XRD confirms the amorphous nature of the AgBGs and, after SBF immersion, reveals their bioactive behavior with the presence of crystalline phase of calcium silicate and phosphorus oxide, which are also detected by FTIR analysis. FTIR also confirms the formation of typical siloxane bonds resulting from the condensation of silicate glass. Lastly, it is found that the developed AgBGs has an antibacterial effect against two different types of bacteria, thus demonstrating their ability to reduce the bacterial infection within 16 h.