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Surface Functionalization of Micro/Nanostructured Titanium with Bioactive Ions to Regulate the Behaviors of Murine Osteoblasts
Author(s) -
Wang Guisen,
Wan Yi,
Ren Bing,
Wang Teng,
Liu Zhanqiang
Publication year - 2017
Publication title -
advanced engineering materials
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.938
H-Index - 114
eISSN - 1527-2648
pISSN - 1438-1656
DOI - 10.1002/adem.201700299
Subject(s) - surface modification , materials science , titanium , osseointegration , nanostructure , nanotechnology , simulated body fluid , surface roughness , chemical engineering , metallurgy , scanning electron microscope , composite material , implant , medicine , engineering , surgery
Surface topography and chemical composition are centrally important in current implants for enhancing cellular responses. To investigate the synergistic effect of micro/nanostructure and bioactive ions on the spreading, proliferation, and differentiation of murine osteoblasts, the micro/nanostructured titanium surface containing bioactive ions (Zn 2+ and Sr 2+ ) was fabricated via sandblasting, acid etching, alkali‐heat treatment, and ion exchange. Compared to polished titanium substrates, micro/nanostructured titanium substrates displayed the enhanced roughness and hydrophilicity. And surface functionalization of micro/nanostructured using Zn 2+ /Sr 2+ ions exhibited the sustained release for a period of time. Meanwhile, cell experiments indicated that the Zn/Sr loaded micro/nanostructured titanium surfaces had a great potential to promote cell spreading, proliferation, and differentiation. This study provides a more promising method to design the surface of titanium implants for enhancing osseointegration.