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Selective Mineralization of Tough Hydrogel Lumens for Simulating Arterial Plaque
Author(s) -
Lao Lihong,
Robinson Sanlin S.,
Peele Bryan,
Zhao Huichan,
Mac Murray Benjamin C.,
Min James K.,
Mosadegh Bobak,
Dunham Simon,
Shepherd Robert F.
Publication year - 2017
Publication title -
advanced engineering materials
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.938
H-Index - 114
eISSN - 1527-2648
pISSN - 1438-1656
DOI - 10.1002/adem.201600591
Subject(s) - materials science , mineralization (soil science) , biomedical engineering , polyacrylamide , lumen (anatomy) , calcium , composite number , crystallization , compressive strength , occlusion , composite material , mineralogy , chemical engineering , chemistry , surgery , metallurgy , medicine , polymer chemistry , engineering , organic chemistry , nitrogen
This paper demonstrates progress of fabricating artificial arteries (phantoms) that mimic plaque buildup. Hydrogel lumens are molded using tough polyacrylamide with regions selectively mineralized with calcium phosphate. By tuning the degree of mineralization such as calcium concentration ([Ca 2+ ], 0.4–2 M), and crystallization time ( t c , 1–4 weeks), the authors control the extent of lumen occlusion. These occluded lumens significantly reduce pressure (Δ P ≈ 7.79 kPa) during fluid flow compared to the non‐calcified lumens (Δ P ≈ 1.24 kPa). Additionally, image, chemical analysis, and compressive mechanical tests are performed to determine the effect of synthesis conditions on the composite's mechanical properties. For comparison to real arteries, the authors also present dynamic mechanical analysis of human aortic tissue.