Premium
Topographical Control of Preosteoblast Culture by Shape Memory Foams
Author(s) -
Xie Ruiqi,
Hu Jinlian,
Guo Xia,
Ng Frankie,
Qin Tingwu
Publication year - 2017
Publication title -
advanced engineering materials
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.938
H-Index - 114
eISSN - 1527-2648
pISSN - 1438-1656
DOI - 10.1002/adem.201600343
Subject(s) - materials science , shape memory polymer , porosity , porous medium , shape memory alloy , composite material , tissue engineering , nanotechnology , biomedical engineering , engineering
Here, the authors present a thermo‐responsive shape memory polymer (SMP) foam that can be programmed to control the preosteoblast behavior by changing porous architecture during cell cultivation. The preosteoblast cells are seeded on the SMP foams with temporarily compressed pore structure. Results show that cells preferentially align along the pore length direction. After the pore recovery at 37 °C, cells remain attached and viable but change their topography in a tangential direction along the pore edge. This work indicates the shape‐memory actuated porous structure in SMP foam can control the cell behavior. This may provide an effective method for studying cell responses to dynamic environment and facilitate the healthy and optimal development of tissue engineering.