Premium
Polyphosphate as a Bioactive and Biodegradable Implant Material: Induction of Bone Regeneration in Rats
Author(s) -
Wang Xiaohong,
Wang Shunfeng,
He Feng,
Tolba Emad,
Schröder Heinz C.,
DiehlSeifert Bärbel,
Müller Werner E. G.
Publication year - 2016
Publication title -
advanced engineering materials
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.938
H-Index - 114
eISSN - 1527-2648
pISSN - 1438-1656
DOI - 10.1002/adem.201600057
Subject(s) - polyphosphate , calvaria , in vivo , materials science , plga , implant , bone morphogenetic protein 2 , biomedical engineering , in vitro , biophysics , phosphate , chemistry , biochemistry , biology , surgery , medicine , microbiology and biotechnology
Inorganic polyphosphate (polyP) is a naturally occurring polymer that is bioresorbable and anabolically active on bone forming cells in vitro. In order to demonstrate if polyP also shows morphogenetic activity in vivo, animal studies are performed applying the rat calvarial defect model. Poly( D,L ‐lactide‐co‐glycolide) (PLGA) microspheres with a narrow size distribution (≈820 μm) are prepared, containing either encapsulated polyP or β‐tricalcium phosphate (β‐TCP), used as a reference material. Discs are prepared from the microspheres and inserted into 10 mm large defects created in the calvaria of rats. Both the formation of COL‐I and the expression of ALP is upregulated, as well as the extent of mineralization within and around the polyP implant. Our data demonstrate that amorphous and resorbable inorganic polyP is also morphogenetically active in vivo.