Premium
A Novel Hybrid‐Structured Titanium Surface Promotes Adhesion of Human Dermal Fibroblasts and Osteogenesis of Human Mesenchymal Stem Cells while Reducing S. epidermidis Biofilm Accumulation
Author(s) -
Park ByungWook,
Krieger Jessica,
Sondag Gregory R.,
Moussa Fouad M.,
Rankenberg Johanna,
Safadi Fayez F.,
Gatsonis Nikolaos A.,
McGimpsey W. Grant,
Lambert Christopher R.,
Malcuit Christopher
Publication year - 2016
Publication title -
advanced engineering materials
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.938
H-Index - 114
eISSN - 1527-2648
pISSN - 1438-1656
DOI - 10.1002/adem.201500282
Subject(s) - biofilm , mesenchymal stem cell , adhesion , cell adhesion , materials science , microbiology and biotechnology , titanium , staphylococcus epidermidis , nanotechnology , tissue engineering , chemistry , biomedical engineering , biology , bacteria , staphylococcus aureus , composite material , medicine , genetics , metallurgy
We provide a comparative analysis of protein adsorption, primary human cell behavior, and biofilm formation on modified titanium substrates of either micro‐, nano‐, or hybrid micro/nano‐scale feature sizes. While studies revealed that nano‐scale structures initially decreased the attachment and spreading of both human fibroblasts (hDFs) and mesenchymal stem cells (hMSCs), hMSC differentiation studies revealed that hybrid structures promoted the highest levels of osteogenic gene expression and attenuated biofilm formation by Staphylococcus epidermidis . Taken together, this novel approach of generating a hybrid topographical feature results in a potential implant material capable of enhanced dermal cell adhesion and osteogenic differentiation while limiting biofilm accumulation.