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Initial Attatchment of rMSC and MG‐63 Cells on Patterned Bioglass® Substrates
Author(s) -
Detsch Rainer,
Guillon Olivier,
Wondraczek Lothar,
Boccaccini Aldo R.
Publication year - 2012
Publication title -
advanced engineering materials
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.938
H-Index - 114
eISSN - 1527-2648
pISSN - 1438-1656
DOI - 10.1002/adem.201180068
Subject(s) - materials science , osteoblast , contact angle , nanotechnology , bone formation , biomedical engineering , in vitro , composite material , chemistry , medicine , biochemistry , endocrinology
A soft lithography technique was used to introduce surface patterns on the surface of sintered bioactive glass substrates. Osteoblast‐like MG‐63 cells and rat mesenchymal stem cells (rMSC) seeded on micropatterned bioactive glass surfaces showed different behavior with rMSC exhibiting a better initial attachment than MG‐63 cells. Both cytoskeleton formation and cell spreading of rMSC were supported by the bioactive surfaces. In addition, the structured surfaces seemed to guide MG‐63 cells to a larger extent than rMSC. The in vitro results are important considering the continuous development of bone tissue scaffolds based on silicate bioactive glasses.