Premium
Bioactive TiOB‐Coating on Titanium Alloy Implants Enhances Osseointegration in a Rat Model
Author(s) -
Schrader Christian,
Schmidt Jürgen,
Diefenbeck Michael,
Mückley Thomas,
Zankovych Sergiy,
Bossert Jörg,
Jandt Klaus D.,
Faucon Mathilde,
Finger Ulrich
Publication year - 2012
Publication title -
advanced engineering materials
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.938
H-Index - 114
eISSN - 1527-2648
pISSN - 1438-1656
DOI - 10.1002/adem.201180032
Subject(s) - osseointegration , materials science , titanium , titanium alloy , plasma electrolytic oxidation , coating , surface modification , alloy , microstructure , anodizing , implant , metallurgy , composite material , chemical engineering , electrolyte , chemistry , surgery , medicine , aluminium , electrode , engineering
The surface properties of titanium alloy implants for improved osseointegration in orthopaedic and dental surgery have been modified by many technologies. Hydroxyapatite coatings with a facultative integration of growth factors deposited by plasma spraying showed improved osseointegration. Our approach in order to enhance osseointegration was carried out by a surface modification method of titanium alloy implants called plasma chemical oxidation (PCO). PCO is an electrochemical procedure that converts the nm‐thin natural occurring titanium‐oxide layer on an implant to a 5 µm thick ceramic coating (TiOB‐surface). Bioactive TiOB‐surfaces have a porous microstructure and were loaded with calcium and phosphorous, while bioinert TiOB‐surfaces with less calcium and phosphorous loadings are smooth. A rat tibial model with bilateral placement of titanium alloy implants was employed to analyze the bone response to TiOB‐surfaces in vivo. 64 rats were randomly assigned to four groups of implants: (i) pure titanium alloy (control), ii) titanium alloy, type III anodization, (iii) bioinert TiOB‐surface, and (iv) bioactive TiOB‐surface. Mechanical fixation was evaluated by pull out tests at 3 and 8 weeks. The bioactive TiOB‐surface showed significantly increased shear strength at 8 weeks compared to all other groups.