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Enhanced Bone Cells Growth and Proliferation on TiO 2 Nanotubular Substrates Treated by RF Plasma Discharge
Author(s) -
Mahmood Meena,
Fejleh Philip,
Karmakar Alokita,
Fejleh Ashley,
Xu Yang,
Kannarpady Ganesh,
Ishihara Hidetaka,
Sharma Rajesh,
Li Zhongrui,
Ghosh Anindya,
Trigwell Steve,
Hardcastle Franklin D.,
Casciano Daniel,
Selvaduray Guna,
Biris Alexandru S.
Publication year - 2011
Publication title -
advanced engineering materials
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.938
H-Index - 114
eISSN - 1527-2648
pISSN - 1438-1656
DOI - 10.1002/adem.201080072
Subject(s) - materials science , osseointegration , titanium , anodizing , biocompatibility , osteoblast , nanotechnology , plasma , adhesion , titanium oxide , chemical engineering , surface modification , implant , composite material , metallurgy , in vitro , aluminium , chemistry , biochemistry , medicine , engineering , physics , surgery , quantum mechanics
Titanium implants are well known for their biocompatibility, especially if bioinertness is desired, due to the TiO 2 native oxide which is thermodynamically and chemically very stable. One of the major problems with this material involve its inability to induce enhanced cellular adhesion and proliferation on its surface without complicated structural approaches, leading to the possible lack of bone‐implant interfacial interaction and rejection. In order to potentially improve osseointegration of such implants self‐assembled vertical and ordered nanotubular TiO 2 arrays were fabricated by electrochemical anodization and were plasma treated under O 2 , N 2 , O 2 + N 2 , and He gaseous environments and their properties analyzed by various analytical procedures. Osteoblast bone cells (MC3T3‐E1) were grown on TiO 2 nanotube‐arrayed substrates and their proliferation was analyzed and quantified. Oxygen and nitrogen plasma treatments were found to significantly improve the proliferation of the bone cells over the TiO 2 nanoarray substrates, with the O 2 + N 2 combination yielding the most significant improvements. These findings may be explained by the interactions between the cells and the changes in the surface chemistry induced by the O 2 and N 2 groups introduced by the plasma discharge treatment onto the TiO 2 surfaces