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Dual‐Growth‐Factor‐Releasing PCL Scaffolds for Chondrogenesis of Adipose‐Tissue‐Derived Mesenchymal Stem Cells
Author(s) -
Lim Sung Mook,
Jang Sung Hwan,
Oh Se Heang,
Yuk Soon Hong,
Im Gun Il,
Lee Jin Ho
Publication year - 2010
Publication title -
advanced engineering materials
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.938
H-Index - 114
eISSN - 1527-2648
pISSN - 1438-1656
DOI - 10.1002/adem.200980153
Subject(s) - chondrogenesis , materials science , mesenchymal stem cell , growth factor , polycaprolactone , tissue engineering , porosity , adipose tissue , biomedical engineering , biophysics , chemistry , microbiology and biotechnology , polymer , composite material , biochemistry , biology , medicine , receptor
Polycaprolactone/Pluronic F127 porous scaffolds are prepared using a modified melt‐molding particulate‐leaching method. The scaffolds are highly porous (about 90% porosity) and have open‐cellular pore structures. Growth factors (TGF‐ β 2 , BMP‐7 or dual TGF‐ β 2 /BMP‐7) can be easily immobilized on the pore surfaces of the PCL/F127 scaffolds via binding with heparin. The growth‐factor‐immobilized scaffolds can induce the chondrogenesis of ATMSCs seeded onto them. Using TGF‐β 2 and BMP‐7 growth factors together leads to a better chondrogenic differentiation behavior than using single‐growth‐factor immobilized scaffolds.