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Development of Biomimetic Chitosan‐Based Hydrogels Using an Elastin‐Like Polymer
Author(s) -
Barbosa Joaquim S.,
Ribeiro Artur,
Testera Ana M.,
Alonso Matilde,
Arias Francisco J.,
RodríguezCabello José C.,
Mano João F.
Publication year - 2010
Publication title -
advanced engineering materials
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.938
H-Index - 114
eISSN - 1527-2648
pISSN - 1438-1656
DOI - 10.1002/adem.200980152
Subject(s) - chitosan , self healing hydrogels , materials science , elastin , polymer , tissue engineering , biomedical engineering , biomaterial , polymer science , composite material , chemical engineering , nanotechnology , polymer chemistry , medicine , pathology , engineering
Chitosan and an elastin‐like polymer, containing a specific osteoconductive sequence in the primary structure, have been combined to obtain bioactive injectable systems with enhanced mechanical properties and hydrogels. Obtained results indicate that the combination of such polymers may be very promising in the development of biomaterials for minimal invasive orthopaedic reconstructive applications or in bone tissue engineering. The figure shows a thermo‐sensitive hydrogel, with a gelation point under physiological temperature.