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Surface Activation of a Ferrimagnetic Glass–Ceramic for Antineoplastic Drugs Grafting
Author(s) -
Vernè Enrica,
Miola Marta,
Ferraris Sara,
Bianchi Claudia L.,
Naldoni Alberto,
Maina Giovanni,
Bretcanu Oana
Publication year - 2010
Publication title -
advanced engineering materials
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.938
H-Index - 114
eISSN - 1527-2648
pISSN - 1438-1656
DOI - 10.1002/adem.200980082
Subject(s) - materials science , graphite furnace atomic absorption , ceramic , wetting , surface modification , distilled water , nuclear chemistry , x ray photoelectron spectroscopy , scanning electron microscope , chemical engineering , analytical chemistry (journal) , composite material , chemistry , mass spectrometry , chromatography , engineering
A ferrimagnetic glass–ceramic, belonging to the system SiO 2 –Na 2 O–CaO–P 2 O 5 –FeO–Fe 2 O 3 , has been studied as potential carrier for antineoplastic agents, in order to exploit the combination of hyperthermia and chemotherapy. Different material pre‐treatments, such as ultrasonic washing, water, or simulated body fluid dipping, were evaluated to promote the surface activation of the glass–ceramic, i.e., the hydroxyl groups formation on it. X‐ray photoelectron spectroscopy, scanning electron microscopy, energy dispersion spectrometry, and wettability measurements were performed to observe the samples surface modification. The best results in terms of free hydroxyl groups exposition were obtained by dipping the samples in distilled water for 7 days at 37 °C. Two different anticancer drugs were selected in order to test the reactivity of the activated surface: cisplatinum and doxorubicin. The uptake and release of doxorubicin and cisplatinum were evaluated on glass–ceramic powders, by using UV–Visible spectrometry and graphite furnace atomic absorption spectroscopy, respectively. After 1 day of uptake at 37 °C, the quantity of doxorubicin incorporated into the glass–ceramic is 77 ± 7 wt%, while only 42 ± 9.6 wt% of cisplatinum is grafted onto the material surface. For both antitumoral agents, the maximum drug release after soaking in aqueous solutions at 37 °C was obtained in few hours, with a randomly distributed kinetics trend.