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Synthesis of Nonwoven Nanofibers by Electrospinning – A Promising Biomaterial for Tissue Engineering and Drug Delivery
Author(s) -
Naveen N.,
Kumar R.,
Balaji S.,
Uma T.S.,
Natrajan T.S.,
Sehgal P.K.
Publication year - 2010
Publication title -
advanced engineering materials
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.938
H-Index - 114
eISSN - 1527-2648
pISSN - 1438-1656
DOI - 10.1002/adem.200980067
Subject(s) - nanofiber , electrospinning , materials science , tissue engineering , drug delivery , biomaterial , chemical engineering , scaffold , kanamycin , antimicrobial , nanotechnology , polymer chemistry , biomedical engineering , composite material , antibiotics , chemistry , polymer , organic chemistry , biochemistry , medicine , engineering
Abstract PHB nanofibers are synthesized by electrospinning of a PHB solution prepared using HFIP as the solvent. The nanofibrous scaffold supports rapid cell growth with normal morphology and attains a viability of 87% after 48 h. Kanamycin sulphate‐loaded PHB nanofiber mats are synthesized, with the antibiotic on the surface and sandwiched within the nanofiber mats: their antimicrobial property is proved by the good zone of inhibition tested against Staphylococcus aureus. The drug shows more than 95% release within 8 h. These results indicate that nanofibers loaded with the antibiotic have potential applications as a template for tissue engineering and as a drug carrier.