Synthesis of Nonwoven Nanofibers by Electrospinning – A Promising Biomaterial for Tissue Engineering and Drug Delivery | Zendy

Naveen N. | Zendy; Kumar R. | Zendy; Balaji S. | Zendy; Uma T.S. | Zendy; Natrajan T.S. | Zendy; Sehgal P.K. | Zendy

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Synthesis of Nonwoven Nanofibers by Electrospinning – A Promising Biomaterial for Tissue Engineering and Drug Delivery

Author(s) -

Naveen N.,

Kumar R.,

Balaji S.,

Uma T.S.,

Natrajan T.S.,

Sehgal P.K.

Publication year - 2010

Publication title -

advanced engineering materials

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 0.938

H-Index - 114

eISSN - 1527-2648

pISSN - 1438-1656

DOI - 10.1002/adem.200980067

Subject(s) - nanofiber , electrospinning , materials science , tissue engineering , drug delivery , biomaterial , chemical engineering , scaffold , kanamycin , antimicrobial , nanotechnology , polymer chemistry , biomedical engineering , composite material , antibiotics , chemistry , polymer , organic chemistry , biochemistry , medicine , engineering

PHB nanofibers are synthesized by electrospinning of a PHB solution prepared using HFIP as the solvent. The nanofibrous scaffold supports rapid cell growth with normal morphology and attains a viability of 87% after 48 h. Kanamycin sulphate‐loaded PHB nanofiber mats are synthesized, with the antibiotic on the surface and sandwiched within the nanofiber mats: their antimicrobial property is proved by the good zone of inhibition tested against Staphylococcus aureus. The drug shows more than 95% release within 8 h. These results indicate that nanofibers loaded with the antibiotic have potential applications as a template for tissue engineering and as a drug carrier.

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