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In Vitro Characteristics of Surface‐Modified Biphasic Calcium Phosphate/Poly( L ‐Lactide) Biocomposite
Author(s) -
Yang Weizhong,
Yin Guangfu,
Zhou Dali,
Gu Jianwen,
Li Yadong
Publication year - 2010
Publication title -
advanced engineering materials
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.938
H-Index - 114
eISSN - 1527-2648
pISSN - 1438-1656
DOI - 10.1002/adem.200980025
Subject(s) - biocomposite , simulated body fluid , materials science , composite number , apatite , microstructure , polylactic acid , chemical engineering , biodegradation , surface modification , calcium , nuclear chemistry , composite material , scanning electron microscope , polymer , chemistry , organic chemistry , engineering , metallurgy
Surface‐modified biphasic calcium phosphate (BCP)/poly( L ‐lactide) (PLLA) biocomposite is shown to have improved microstructure and mechanical properties compared to the unmodified system. In vitro biodegradation and bioactivity of the composite are investigated in simulate body fluid for up to four weeks. Weight changes of the samples and the pH changes of the SBF are recorded. Surface properties of the composite after immersion are characterized by XRD, SEM and EDX analyses. Cyto‐compatibility was determined by MTT assay with L929 mouse fibroblasts. The difference of the degradation behavior between modified BCP/PLLA and the reference unmodified composite are investigated, and mBCP/PLLA composite is proved to be a better as a scaffold material. The surface formed bio‐apatite layer after immersion shows the excellent bioactivity of the mBCP/PLLA composite. L929 cells show a high growth rate and proliferation, demonstrating the good cytocompatibility of mBCP/PLLA composite.