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Synthesis, Characterization and Drug Release Behavior of pH‐Responsive O‐carboxymethyl Chitosan‐graft‐poly(N‐vinylpyrrolidone) Hydrogel Beads
Author(s) -
Ma Liwei,
Liu Mingzhu,
Chen Jun,
Liu Hongliang,
Cui Dapeng,
Gao Chunmei
Publication year - 2009
Publication title -
advanced engineering materials
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.938
H-Index - 114
eISSN - 1527-2648
pISSN - 1438-1656
DOI - 10.1002/adem.200900149
Subject(s) - chitosan , grafting , n vinylpyrrolidone , copolymer , materials science , polymer chemistry , ionic bonding , drug , chemical engineering , nuclear chemistry , chemistry , ion , organic chemistry , polymer , composite material , pharmacology , medicine , engineering
In this work, the carboxymethyl chitosan (CMCTS) grafted poly(N‐vinylpyrrolidone) (PVP) copolymers were synthesized. The hydrogel beads containing VB 2 were prepared from the copolymers by an ionic crosslinked. The experimental results shown that VB 2 drug release rate from those beads decreased with the increasing grafting percentage, crosslinker concentration and pH value of the medium. Besides, the beads have the better control ability for releasing of model drug than CMCTS does.