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Fabrication and Evaluation of Chitin‐Based Nerve Guidance Conduits Used to Promote Peripheral Nerve Regeneration
Author(s) -
Yang Yumin,
Wu Jian,
Wang Xiaodong,
Liu Jie,
Ding Fei,
Gu Xiaosong
Publication year - 2009
Publication title -
advanced engineering materials
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.938
H-Index - 114
eISSN - 1527-2648
pISSN - 1438-1656
DOI - 10.1002/adem.200900120
Subject(s) - chitin , chitosan , regeneration (biology) , sciatic nerve , nerve guidance conduit , biocompatible material , materials science , peripheral nerve , biomedical engineering , peripheral nerve injury , bridge (graph theory) , peripheral , peripheral nervous system , anatomy , microbiology and biotechnology , medicine , biology , neuroscience , central nervous system , biochemistry
Chitin product was prepared from the chitosan counterpart and both were found to be equally biocompatible with cultured Schwann cells. Chitin‐ and chitosan‐based nerve guidance conduits (NGCs) were surgically implanted to bridge 10‐mm‐long neural defects in rat sciatic nerves. The regenerative outcome provided positive evidence that chitin‐ and chitosan‐based NGCs produce the similar beneficial effects on peripheral nerve regeneration.