Premium
Formation and Topotactical Orientation of Fibrinogen Nanofibrils on Graphite Nanostructures
Author(s) -
Reichert Jörg,
Wei Gang,
Jandt Klaus D.
Publication year - 2009
Publication title -
advanced engineering materials
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.938
H-Index - 114
eISSN - 1527-2648
pISSN - 1438-1656
DOI - 10.1002/adem.200900084
Subject(s) - fibrinogen , thrombin , materials science , nanostructure , nanotechnology , atomic force microscopy , molecule , biophysics , chemistry , platelet , biochemistry , organic chemistry , biology , immunology
We studied the adsorption of human plasma fibrinogen and investigated the formation of amyloid‐like fibrinogen nanofibrils and fibrinogen networks in the absence of thrombin and Ca·2+ with high resolution atomic force microscopy (AFM). We propose a possible mechanisms for the surface nanostructure mediated self assembly of fibrinogen molecules and the formation of fibrinogen nanofibrils and nanofibril networks in the absence of thrombin.