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Interaction of Osteoblasts with Macroporous Scaffolds Made of PLLA/PCL Blends Modified with Collagen and Hydroxyapatite
Author(s) -
Aydin Halil Murat,
Yang Ying,
Kohler Thomas,
Haj Alicia El,
Müller Ralph,
Pişkin Erhan
Publication year - 2009
Publication title -
advanced engineering materials
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.938
H-Index - 114
eISSN - 1527-2648
pISSN - 1438-1656
DOI - 10.1002/adem.200900030
Subject(s) - materials science , scaffold , porosity , coating , leaching (pedology) , polymer , supercritical fluid , homogeneous , chemical engineering , extraction (chemistry) , composite material , tissue engineering , matrix (chemical analysis) , biomedical engineering , chromatography , chemistry , organic chemistry , environmental science , physics , soil science , soil water , engineering , thermodynamics , medicine
To mimic natural bone, a tissue engineering scaffold was developed that combines inorganic and organic components of natural bone, its pore diameter, and its interconnected structure. Collagen was coated onto a PLLA/PCL scaffold and hydroxyapatite particles were delivered throughout the polymer matrix much more easily than with other techniques thanks to the porosity‐forming method of combining two porogens, namely, salt leaching and supercritical CO 2 extraction. Compared with other coating techniques, this procedure can be performed readily and homogeneous 3D hydroxyapatite coating was achieved.