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A Short‐Term Bioresorbable Bone Filling Material Based on Hydroxyapatite, Chitosan, and Oxidized Starch Tested in a Novel Orthotopic Metaphyseal Mouse Model
Author(s) -
Volkmer Elias,
Hoffmann Bettina,
Kokott Andreas,
Drosse Inga,
Neunhoeffer AnnaKatharina,
Haasters Florian,
Seitz Sebastian,
Stengele Michael,
Ziegler Günther,
Mutschler Wolf,
Schieker Matthias
Publication year - 2009
Publication title -
advanced engineering materials
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.938
H-Index - 114
eISSN - 1527-2648
pISSN - 1438-1656
DOI - 10.1002/adem.200800351
Subject(s) - chitosan , materials science , biocompatibility , biomedical engineering , biomaterial , starch , in vivo , covalent bond , nanotechnology , chemistry , medicine , biochemistry , metallurgy , microbiology and biotechnology , organic chemistry , biology
Despite significant advances in orthopedic surgery, no perfect bioresorbable bone‐filling material has yet been clinically established. A new candidate material based on hydroxyapatite, chitosan and oxidised starch, which has the potential to covalently bind to bone in a watery milieu was tested in a new murine model. A special focus lies on the in vivo biocompatibility and bioresorbability of the new material.