Premium
A Novel Biodegradable and Light‐Breakable Diblock Copolymer Micelle for Drug Delivery
Author(s) -
Xie Zhigang,
Hu Xiuli,
Chen Xuesi,
Mo Guojun,
Sun Jing,
Jing Xiabin
Publication year - 2009
Publication title -
advanced engineering materials
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.938
H-Index - 114
eISSN - 1527-2648
pISSN - 1438-1656
DOI - 10.1002/adem.200800254
Subject(s) - copolymer , micelle , materials science , drug delivery , pyrene , chemical engineering , polymer chemistry , nanotechnology , organic chemistry , polymer , chemistry , aqueous solution , composite material , engineering
A facile approach to the preparation of light‐responsive copolymer micelles is developed. This approach is based on the attachment of hydrophobic groups to one block of a diblock copolymer via a light‐sensitive linkage. The micelles can be dissociated under light irradiation and release the encapsulated pyrene. The obtained polymeric micelles are expected to be of use as drug‐delivery vehicles.